Potassium Hydroxide → HCID 66820586, compound

5-Bromo-N2,N2-dimethylpyridine-2,3-diamine (53 mg, 0.25 mmol) was taken into THF (2 mL) followed by addition of diisopropylethylamine (213 uL, 1.25 mmol) and methanesulfonyl chloride (95 ul, 1.25 mmol). The mixture was allowed to stir for 48 h at room temperature then partitioned with ethyl acetate and water. The organic phase was washed with brine then dried over sodium sulfate, filtered and concentrated. The residue was taken into methanol (3 mL) followed by addition of potassium hydroxide (108 mg, 10 eq) in a minimum of water. The mixture was stirred for 15 minutes at room temperature then partitioned with ethyl acetate and 10% aqueous citric acid. The organic solution was dried over magnesium sulfate, filtered and concentrated. The residue was purified by silica gel chromatography to give N-(5-bromo-2-(dimethylamino)pyridin-3-yl)methanesulfonamide (27.9 mg, 39%). MS (EI) for C8H12N3SO2Br: 294, 296 (MH+, Br pattern).

1. customthen partitioned with ethyl acetate and water
2. washThe organic phase was washed with brine
3. dry with materialthen dried over sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. stirringThe mixture was stirred for 15 minutes at room temperature
7. customthen partitioned with ethyl acetate and 10% aqueous citric acid
8. dry with materialThe organic solution was dried over magnesium sulfate
9. filtrationfiltered
10. concentrationconcentrated
11. customThe residue was purified by silica gel chromatography

ORD record

ord-38314a3a972f4bccae2e719cc0302d25

Source dataset

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08648066B2