4-Iodobenzoyl chloride → [4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanone

HRID 2411264Notes

Reaction equation

HRID 2411264 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:15])[C:6]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:7][CH:8]=1)[CH3:2].[I:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[CH2:1]([C:3]1[CH:4]=[C:5]([CH3:15])[C:6]([N:9]2[CH2:10][CH2:11][N:12]([C:21]([C:20]3[CH:24]=[CH:25][C:17]([I:16])=[CH:18][CH:19]=3)=[O:22])[CH2:13][CH2:14]2)=[N:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 743734-Iodobenzoyl chlorideHCID 584845781-(5-Ethyl-3-methylpyridin-2-yl)piperazine

Product 1

HCID 58484605[4-(5-Ethyl-3-methylpyridin-2-yl)piperazin-1-yl](4-iodophenyl)methanoneYield 90.5%

Procedure

Using 1-(5-ethyl-3-methylpyridin-2-yl)piperazine (2.46 g) described in Preparation Example 81 and 4-iodobenzoyl chloride (3.36 g) and by the reaction and treatment in the same manner as in Preparation Example 108, the title compound (4.72 g) was obtained.

Sources & evidence

ORD record
ord-f586afa178084685aaac472a456578e9
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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