Sodium Iodide → HCID 71251989, compound

HRID 2411295Notes

Reaction equation

HRID 2411295 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[C:21]([CH3:22])=[CH:20][C:19]([CH3:23])=[CH:18][N:17]=3)[CH2:12][CH2:11]2)=[O:9])=[CH:4][C:3]=1[F:24].[I-:25].[Na+]>[Cu]I>[CH3:22][C:21]1[C:16]([N:13]2[CH2:14][CH2:15][N:10]([C:8]([C:5]3[CH:6]=[CH:7][C:2]([I:25])=[C:3]([F:24])[CH:4]=3)=[O:9])[CH2:11][CH2:12]2)=[N:17][CH:18]=[C:19]([CH3:23])[CH:20]=1

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 58484572(4-Bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 71251989HCID 71251989, compoundYield 70.5%

Reagents, catalysts & solvents 1

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)Catalyst

Procedure

Using (4-bromo-3-fluorophenyl)[4-(3,5-dimethylpyridin-2-yl)piperazin-1-yl]methanone (760 mg) described in Preparation Example 125, sodium iodide (581 mg) and copper(I) iodide (184 mg) and by the reaction and treatment in the same manner as in Preparation Example 154, the title compound (600 mg) was obtained.

Sources & evidence

ORD record
ord-0c096f0d9f6945d1b0dda4876372fc0f
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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