3-Chloropropanesulphonyl chloride → HCID 71252031, compound

HRID 2411610Notes

Reaction equation

HRID 2411610 reaction equation
FC1N=CC(C(N2CCN(C3C=C(C)C(C)=CC=3C)CC2)=O)=C(C)C=1.COC1C=CC(CN)=CC=1.Cl[CH2:37][CH2:38][CH2:39][S:40](Cl)(=[O:42])=[O:41].[NH2:44][C:45]1[N:50]=[CH:49][C:48]([C:51]([N:53]2[CH2:58][CH2:57][N:56]([C:59]3[CH:64]=[C:63]([CH3:65])[C:62]([CH3:66])=[CH:61][C:60]=3[CH3:67])[CH2:55][CH2:54]2)=[O:52])=[C:47]([CH3:68])[CH:46]=1>>[O:41]=[S:40]1(=[O:42])[CH2:39][CH2:38][CH2:37][N:44]1[C:45]1[N:50]=[CH:49][C:48]([C:51]([N:53]2[CH2:54][CH2:55][N:56]([C:59]3[CH:64]=[C:63]([CH3:65])[C:62]([CH3:66])=[CH:61][C:60]=3[CH3:67])[CH2:57][CH2:58]2)=[O:52])=[C:47]([CH3:68])[CH:46]=1

Participants

5

Reactant 4

HCID 154103-Chloropropanesulphonyl chlorideHCID 754524-MethoxybenzylamineHCID 71252217HCID 71252217, compoundHCID 71252409HCID 71252409, compound

Product 1

HCID 71252031HCID 71252031, compound

Procedure

Using (6-fluoro-4-methylpyridin-3-yl)[4-(2,4,5-trimethylphenyl)piperazin-1-yl]methanone (310 mg) described in Preparation Example 180, 4-methoxybenzylamine (2 mL) and 3-chloropropane-1-sulfonyl chloride (0.23 mL) and by the reaction and treatment in the same manner as in Example 229, the title compound (185 mg) was obtained via (6-amino-4-methylpyridin-3-yl)[4-(2,4,5-trimethylphenyl)piperazin-1-yl]methanone.

Sources & evidence

ORD record
ord-3d7b3b21d4a9415c9b9094f4485f6ee3
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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