Methyl p-toluenesulfonate → HCID 71252828, compound

HRID 2411647Notes

Reaction equation

HRID 2411647 reaction equation
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[C@H:27]([CH2:28][OH:29])[CH2:26][CH2:25][C:24]4=[O:30])=[CH:19][C:18]=3[S:31]([CH3:34])(=[O:33])=[O:32])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.S(C1C=CC(C)=CC=1)(O[CH3:39])(=O)=O>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[C@H:27]([CH2:28][O:29][CH3:39])[CH2:26][CH2:25][C:24]4=[O:30])=[CH:19][C:18]=3[S:31]([CH3:34])(=[O:33])=[O:32])=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1

Participants

3

Reactant 2

HCID 6645Methyl p-toluenesulfonateHCID 71251927HCID 71251927, compound

Product 1

HCID 71252828HCID 71252828, compoundYield 27.7%

Procedure

Using (S)-1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-3-methanesulfonylphenyl}-5-hydroxymethylpyrrolidin-2-one (530 mg) described in Example 274 and methyl tosylate (203 mg) and by the reaction and treatment in the same manner as in Example 36, the title compound (151 mg) was obtained.

Sources & evidence

ORD record
ord-894ddeee476642fe88bd383504e3b693
Source dataset
uspto-grants-2014_08
Patent number
US08816079B2

Reaction notes

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