Triethylamine → HCID 86739861, compound

HRID 2412315Notes

Reaction equation

HRID 2412315 reaction equation
C(N(CC)CC)C.[C:8]([OH:14])(=[O:13])[CH2:9][CH:10]([CH3:12])[CH3:11].[F:15][CH:16]([CH2:18][C:19](Cl)=[S:20])[F:17]>O1CCCC1>[C:8]([O:14][C:19](=[S:20])[CH2:18][CH:16]([F:17])[F:15])(=[O:13])[CH2:9][CH:10]([CH3:12])[CH3:11]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 10430Isovaleric AcidHCID 19880176HCID 19880176, compound

Product 1

HCID 86739861HCID 86739861, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of triethylamine (1.4 equivalents) and isovaleric acid (1.3 equivalents) in tetrahydrofuran (5 parts by weight) is dropwise added difluoromethylthioacetyl chloride at -30° C., and the mixture is left standing for 1 hour. After removing separated crystals by filtration, the reaction mixture is concentrated in vacuum to leave difluoromethylthioacetic isovaleric anhydride.

Workup

  1. customat -30° C.
  2. waitthe mixture is left
  3. customAfter removing
  4. customseparated crystals
  5. filtrationby filtration
  6. concentrationthe reaction mixture is concentrated in vacuum

Sources & evidence

ORD record
ord-a1b96fd5b4014a17af99cdbc9fc848f0
Source dataset
uspto-grants-1985_01
Patent number
US04491547

Reaction notes

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