反应详情

To a solution of 4-amino-2-methyl-1,2,3-triazole-5-carbonitrile (1.7 g) in tetrahydrofuran (35 ml) under nitrogen, was added sodium hydride (1.0 g; 50% oil dispersion) at room temperature. After 15 minutes, 2,5-difluoronitrobenzene(2.22 g) was added to the mixture, which was stirred overnight under nitrogen. The deep red solution was then quenched in ice/water/HCl and filtered to give an orange solid. The solid was chromatographed on a magnesium silicate column using dichloromethane; the purified product recrystallised from ethyl acetate-ethanol to give an orange crystalline solid, melting point 159°-160° C.

1. customThe deep red solution was then quenched in ice/water/HCl
2. filtrationfiltered
3. customto give an orange solid
4. customThe solid was chromatographed on a magnesium silicate column
5. customthe purified product recrystallised from ethyl acetate-ethanol
6. customto give an orange crystalline solid, melting point 159°-160° C.