O-Methylhydroxylamine → N-(5-tert-Butyl-1,2-oxazol-3-yl)-N'-methoxyurea

HRID 2412533Notes

Reaction equation

HRID 2412533 reaction equation
[CH3:1][O:2][NH2:3].[N:4]([C:7]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[O:9][N:8]=1)=[C:5]=[O:6]>O1CCCC1>[CH3:1][O:2][NH:3][C:5]([NH:4][C:7]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[O:9][N:8]=1)=[O:6]

Participants

4

Reactant 2

HCID 4113O-MethylhydroxylamineHCID 129188385-Tert-butyl-3-isocyanato-1,2-oxazole

Product 1

HCID 13370466N-(5-tert-Butyl-1,2-oxazol-3-yl)-N'-methoxyurea

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

8.5 g of methoxyamine was added very slowly to a stirred solution of 15 g of 4A in 600 ml of tetrahydrofuran. The resulting mixture was filtered and the solid was triturated with ether to give 1-methoxy-3-(5-(tertiary-butyl)-1,2-oxazol-3-yl)urea (4B), m.p.: 145°-148° C.

Workup

  1. filtrationThe resulting mixture was filtered
  2. customthe solid was triturated with ether

Sources & evidence

ORD record
ord-913f2808d8284d4d91ad6f7602ea6369
Source dataset
uspto-grants-1985_01
Patent number
US04493728

Reaction notes

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