Hydrochloric Acid → HCID 12799926, compound

HRID 2412603Notes

Reaction equation

HRID 2412603 reaction equation
[CH2:1]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([C:17]([OH:19])=[O:18])=[CH:12][CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Cl.O.[CH2:22](O)[CH3:23]>>[CH2:1]([C:8]1[NH:9][C:10]2[C:15]([CH:16]=1)=[CH:14][C:13]([C:17]([O:19][CH2:22][CH3:23])=[O:18])=[CH:12][CH:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 702Ethanol2×HCID 962WaterHCID 12797223HCID 12797223, compound

Product 1

HCID 12799926HCID 12799926, compound

Procedure

A solution of 2-(n-heptyl)indole-5-carboxylic acid (18.4 g) in ethanol (80 ml) containing a solution of hydrogen chloride gas in ethanol (110 ml, of strength 34% w/v) was refluxed for 6 hours. The solution was poured into water and the solid was collected and was recrystallised from methanol to give ethyl 2-(n-heptyl)indole-5-carboxylate (10.7 g), in the form of buff crystals, m.p. 66°-69° C.

Workup

  1. temperaturewas refluxed for 6 hours
  2. customthe solid was collected
  3. customwas recrystallised from methanol

Sources & evidence

ORD record
ord-26ff6c51598f465fb3c27d61c91ec8e4
Source dataset
uspto-grants-1985_01
Patent number
US04493843

Reaction notes

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