Hydrochloric Acid → HCID 12799928, compound

HRID 2412607Notes

Reaction equation

HRID 2412607 reaction equation
[CH2:1]([C:13]1[NH:14][C:15]2[C:20]([CH:21]=1)=[CH:19][C:18]([C:22]([OH:24])=[O:23])=[CH:17][CH:16]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].Cl.[CH2:26](O)[CH3:27]>>[CH2:1]([C:13]1[NH:14][C:15]2[C:20]([CH:21]=1)=[CH:19][C:18]([C:22]([O:24][CH2:26][CH3:27])=[O:23])=[CH:17][CH:16]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702Ethanol2×HCID 12797226HCID 12797226, compound

Product 1

HCID 12799928HCID 12799928, compound

Procedure

A solution of 2-(n-dodecyl)indole-5-carboxylic acid (13.8 g) in ethanol (80 ml) containing a solution of hydrogen chloride gas in ethanol (100 ml of strength 39% w/v) was refluxed for 6 hours. The solid which separated on cooling was collected and was recrystallised from ethanol to give ethyl 2-(n-dodecyl)indole-5-carboxylate (11.2 g), in the form of a buff powder, m.p. 77°-79° C.

Workup

  1. temperaturewas refluxed for 6 hours
  2. customThe solid which separated
  3. temperatureon cooling
  4. customwas collected
  5. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-b20333bdff834aa388aeface28176abc
Source dataset
uspto-grants-1985_01
Patent number
US04493843

Reaction notes

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