反应详情

A solution of 2-(n-pentadecyl)indole-5-carboxylic acid (15.0 g) in methanol (100 ml) containing aqueous hydrochloric acid (10 ml, of strength 36.5% w/v) was refluxed for 5 hours. After cooling, the mixture was dissolved in a mixture of diethyl ether and tetrahydrofuran (1:1). The solution was washed with water (2×50 ml), dried over sodium sulphate, evaporated in vacuo, and the residue was recrystallised from methanol to give methyl 2-(n-pentadecyl)indole-5-carboxylate (12.2 g), in the form of an off-white powder, m.p. 89°-92° C.

1. temperaturewas refluxed for 5 hours
2. temperatureAfter cooling
3. washThe solution was washed with water (2×50 ml)
4. dry with materialdried over sodium sulphate
5. customevaporated in vacuo
6. customthe residue was recrystallised from methanol