Hydrochloric Acid → 2-Phenylethylamine hydrochloride

HRID 2412656Notes

Reaction equation

[C:1]1([CH2:7][CH2:8][NH:9]P(=O)(OC(C)C)OC(C)C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(OC(C)C)(C)C.[ClH:27]>>[ClH:27].[C:1]1([CH2:7][CH2:8][NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 7914Diisopropyl Ether

HCID 12856530HCID 12856530, compound

Product 1

HCID 90752-Phenylethylamine hydrochloride

Procedure

A solution of 1.425 g. (5 millimols) diisopropyl N-(2-phenylethyl)-phosphoramidate in 20 ml. diisopropyl ether saturated with hydrogen chloride is stirred overnight at ambient temperature. The precipitate of 2-phenylethylamine hydrochloride formed is filtered off, washed with diisopropyl ether and then dried in vacuo to give 0.75 g. (yield: 95%) of a crystalline solid, the physical and spectral characteristics of which are identical to those of the compound prepared in Example 2.

Sources & evidence

ORD record: ord-54ba6d88bafc4505a372a57d384711f3
Source dataset: uspto-grants-1985_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04493931

Reaction notes

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