2-Chloropyridine → HCID 13199808, compound

HRID 2412856Notes

Reaction equation

HRID 2412856 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[Br:8][CH2:9][C:10]([O:12][CH3:13])=[O:11]>>[Br-:8].[CH3:13][O:12][C:10]([CH2:9][N+:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])=[O:11]

Participants

3

Reactant 2

HCID 79772-ChloropyridineHCID 60984Methyl bromoacetate

Product 1

HCID 13199808HCID 13199808, compoundYield 46.4%

Conditions

Temperature
60 °C

Procedure

A mixture of 2-chloropyridine (16 g) and methyl bromoacetate (72 g) was allowed to stand for one week at room temperature and then heated for 7 hours at 60° C. The resulting precipitates were collected by filtration and washed with diethyl ether to give 1-methoxycarbonylmethyl-2-chloropyridinium bromide (17.43 g), mp. 163° to 165° C.

Workup

  1. waitto stand for one week at room temperature
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-8dbb328da2184094a8634363ca05823f
Source dataset
uspto-grants-1985_01
Patent number
US04495182

Reaction notes

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