反应详情

(2-Methylphenoxymethyl)oxirane, 4.1 g. (0.025 mole) and 6.65 g. (0.025 mole) of 5-bromo-α,α-dimethyl-1H-indol-3-yl-ethaneamine were mixed and heated at 140° for 1 hr. The mixture was then cooled and dissolved in 40 ml. of acetonitrile while still warm. The product was converted to the hydrochloride salt by treatment of the solution with 5 N ethanolic HCl. The solvent was removed by distillation and the residue dissolved in 30 ml. of acetonitrile. The product crystallized from this solution, yield 11.0 g., m.p. 197°-199°. This material was recrystallized from methanol/isopropanol, yield 8.0 g., m.p. 198.0°-200.0° dec. (corr.).

1. temperatureheated at 140° for 1 hr
2. temperatureThe mixture was then cooled
3. dissolutiondissolved in 40 ml
4. customThe solvent was removed by distillation
5. dissolutionthe residue dissolved in 30 ml
6. customThe product crystallized from this solution, yield 11.0 g
7. customThis material was recrystallized from methanol/isopropanol, yield 8.0 g