Salicylic Acid → 2,3-Dihydroxybenzoic Acid

HRID 2413521Notes

Reaction equation

HRID 2413521 reaction equation
C([O-])(=O)CC(CC([O-])=O)(C([O-])=O)[OH:4].C(N)(=O)C1CC=CNC=1.[C:23]([OH:32])(=[O:31])[C:24]1[C:25](=[CH:27][CH:28]=[CH:29][CH:30]=1)[OH:26]>>[OH:26][C:25]1[C:27]([OH:4])=[CH:28][CH:29]=[CH:30][C:24]=1[C:23]([OH:32])=[O:31]

Participants

4

Reactant 3

HCID 338Salicylic AcidHCID 31348CitrateHCID 135865461,4-Dihydropyridine-3-carboxamide

Product 1

HCID 192,3-Dihydroxybenzoic Acid

Procedure

The process is conducted in a manner similar to that described in Example 1 hereinbefore, except that 1 ml of the citrate buffer, 1 mg of cellulose modified with 1,4-dihydronicotinamide and 0.03 mg of 9-methyl-phenazium methyl sulfate and 0.3 mg. of salicylic acid are used. As a result, 0.28 mg. of 2,3-dihydroxybenzoic acid is obtained (95% as calculated for the starting compound) having m.p. 203°-204° C. The composition, in %, is as follows:

Sources & evidence

ORD record
ord-16114f7a6e4547608b8431ae2ec21df9
Source dataset
uspto-grants-1988_01
Patent number
US04718994

Reaction notes

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