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HRID2413676

反应详情

EQUATION

反应方程式

HRID 2413676 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：NNc1ccccc1
HCID7516

Phenylhydrazine

C6H8N2

结构：[Na+].[OH-]
HCID14798

Sodium Hydroxide

HNaO

结构：COc1ccc(C(=O)C=Cc2ccc([N+](=O)[O-])cc2)cc1
HCID237433

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(C2=NN(c3ccccc3)C(c3ccc([N+](=O)[O-])cc3)C2)cc1
HCID4436503

4,5-Dihydro-3-(4-methoxyphenyl)-5-(4-nitrophenyl)-1-phenyl-1H-pyrazole

C22H19N3O3

收率 78.8%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CCO
溶剂HCID702

Ethanol

C2H6O

结构：O
溶剂HCID962

Water

H2O

2 次

PROCEDURE

实验过程

14.2 g of 4'-methoxy-4-nitrochalcone was reacted with 5.4 g of phenylhydrazine in 100 ml of ethanol in the presence of 5 ml of hydrochloric acid by refluxing while heating for 6 hours. After neutralizing the reaction mixture with 50 ml of 1N NaOH, 400 ml of water was added thereto. Decantation-water washing was repeated three times. Crystals formed were recrystallized from 200 ml of acetone to obtain 14.7 g of the desired compound. m.p. 168°-173° C.

WORKUP

后处理

  1. temperatureby refluxing
  2. temperaturewhile heating for 6 hours
  3. additionwas added
  4. customCrystals formed
  5. customwere recrystallized from 200 ml of acetone