HCID 54540367, compound → HCID 20155611, compound

HRID 2413833Notes

Reaction equation

C([O:3][C:4]([C:6]1[C:19](=[O:20])[C:18]2[C:9](=[C:10]3[C:15](=[C:16]([F:21])[CH:17]=2)[N:14]([CH2:22][CH3:23])[CH:13]=[C:12]([C:24]([O:26]CC)=[O:25])[C:11]3=[O:29])[N:8]([CH2:30][CH3:31])[CH:7]=1)=[O:5])C>Cl>[CH2:30]([N:8]1[C:9]2[C:18](=[CH:17][C:16]([F:21])=[C:15]3[C:10]=2[C:11](=[O:29])[C:12]([C:24]([OH:26])=[O:25])=[CH:13][N:14]3[CH2:22][CH3:23])[C:19](=[O:20])[C:6]([C:4]([OH:5])=[O:3])=[CH:7]1)[CH3:31]

Participants

Conditions

Temperature: 90 °C

Procedure

A mixture of 0.935 g (2.17 mmol) of the compound of Example 2 and 20 ml of 6N HCl is stirred at 90° C. for 4 hours. After cooling, the mixture is concentrated under reduced pressure. The residue is triturated with cold ethanol to furnish 0.334 g (41.1%) of title compound as a tan solid:

Workup

temperatureAfter cooling
concentrationthe mixture is concentrated under reduced pressure
customThe residue is triturated with cold ethanol

Sources & evidence

ORD record: ord-b1821cff399744dc9fa82ed48273a12b
Source dataset: uspto-grants-1988_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04719302

Reaction notes

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