Methanol → HCID 13990998, compound

HRID 2413874Notes

Reaction equation

HRID 2413874 reaction equation
[CH:1]([O-])([O-])[O:2][CH3:3].[C:6]1([CH3:16])[C:7](S(O)(=O)=O)=[CH:8][CH:9]=[CH:10][CH:11]=1.C(N([CH2:22][CH3:23])CC)C.[CH3:24][OH:25]>>[CH3:3][O:2][C:1]1[CH2:23][CH2:22][C@H:7]2[C:6](=[CH:11][CH2:10][C@@H:9]3[C@@H:8]2[CH2:8][CH2:7][C@@:6]2([CH3:16])[C@H:11]3[CH2:10][CH2:9][C:24]2=[O:25])[CH:16]=1

Participants

5

Reactant 4

HCID 887MethanolHCID 69252-Methylbenzenesulfonic acidHCID 8471TriethylamineHCID 53629101Methylorthoformate

Product 1

HCID 13990998HCID 13990998, compoundYield 69%

Procedure

1-3-methoxy 17-oxo estra 3,5-diene 10 g 3, 17-dioxo estra 4-ene in 50 ml methanol are mixed under stirring with 10 ml methyl orthoformate and 50 mg p. toluene sulphonic acid. Few drops of triethylamine are added thereto then the mixture is chilled and the crystalls are separated then dried--3-methoxy 17-oxo estra 3, 5-diene are thus obtained with a yield of 69%.

Workup

  1. temperaturethe mixture is chilled
  2. customthe crystalls are separated
  3. customthen dried

Sources & evidence

ORD record
ord-4f924fbf09704e47b3c0dd4b82dea288
Source dataset
uspto-grants-1988_01
Patent number
US04720357

Reaction notes

Loading…