2-Amino-2-methyl-1,3-propanediol → 1,3-Propanediol, 2-((8-fluoranthenylmethyl)amino)-2-methyl-, hydrochloride

HRID 2414042Notes

Reaction equation

[ClH:1].[CH:2]1[C:16]2=[C:17]3[C:9]([C:10]4[C:15]2=[CH:14][CH:13]=[CH:12][CH:11]=4)=[CH:8][CH:7]=[CH:6][C:5]3=[C:4]([CH2:18][NH:19][C:20]([CH3:25])([CH2:23][OH:24])[CH2:21][OH:22])[CH:3]=1.C1C2=C3C(C4C2=CC=C(C=O)C=4)=CC=CC3=CC=1.CC(N)(CO)CO>>[ClH:1].[CH:14]1[C:15]2=[C:10]3[C:9]([C:17]4[C:16]2=[CH:2][CH:3]=[C:4]([CH2:18][NH:19][C:20]([CH3:25])([CH2:23][OH:24])[CH2:21][OH:22])[CH:5]=4)=[CH:8][CH:7]=[CH:6][C:11]3=[CH:12][CH:13]=1

Participants

Reactant 3

HCID 15312-Amino-2-methyl-1,3-propanediol

HCID 3024572773U82 Hydrochloride

HCID 114361558-Fluoranthenecarboxaldehyde

Product 1

HCID 1504091,3-Propanediol, 2-((8-fluoranthenylmethyl)amino)-2-methyl-, hydrochloride

Procedure

Using the reductive amination procedure outlined in 1D, 8-fluoranthenecarbaldehyde (1C) and 2-methyl-2-amino-1,3-propanediol (Aldrich) gave 2-((8-fluoranthenylmethyl)amino)-2-methyl-1,3-propanediol hydrochloride mp 233°-234.5° (dec), (CH3OH/Et2O), (C, H, Cl, N).

Sources & evidence

ORD record: ord-285d186b51e84451b4c554fc48568c72
Source dataset: uspto-grants-1988_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04720587

Reaction notes

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