4-Bromobutyronitrile → HCID 20153795, compound

HRID 2414074Notes

Reaction equation

HRID 2414074 reaction equation
[NH2:1][C:2]1[N:3]=[N:4][C:5]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[Br:20][CH2:21][CH2:22][CH2:23][C:24]#[N:25]>CN(C)C=O>[Br-:20].[NH2:1][C:2]1[N:3]([CH2:21][CH2:22][CH2:23][C:24]#[N:25])[NH2+:4][C:5]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 214124-BromobutyronitrileHCID 11770746HCID 11770746, compound

Product 1

HCID 20153795HCID 20153795, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

2.47 g of 3-amino-4,6-diphenylpyridazine are dissolved in 5 ml of dimethylformamide, and 1.63 g of 4-bromobutyronitrile are added. The mixture is heated at 60° C. for 2 hours and left to cool. The crystals formed are filtered off and recrystallised from isopropanol. Melting point=202°-204° C.

Workup

  1. waitleft
  2. temperatureto cool
  3. customThe crystals formed
  4. filtrationare filtered off
  5. customrecrystallised from isopropanol

Sources & evidence

ORD record
ord-db14b143d50a4b56b89754337be87ff3
Source dataset
uspto-grants-1988_01
Patent number
US04721711

Reaction notes

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