反应详情

温度

25 °C

A solution of 4-methoxy-α-toluenethiol (7.7 g, 0.05 mol) in DMF (10 ml) was added dropwise to a stirred mixture of sodium hydride (2.50 g, 50% oil dispersion, 0.054 mol) in DMF (40 ml). When gas evolution was complete, N,N-dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine (14.85 g; 0.05 mol) was added and the resulting mixture was stirred for 1 hour at 25° C. The reaction mixture was diluted with water and the solid that separated was collected, washed with water and dried to give 15.36 g., m.p. 92°-101° C. Recrystallization from 1-chlorobutane gave material with m.p. 110°-111.5° C.

1. customthe solid that separated
2. customwas collected
3. washwashed with water
4. customdried
5. customto give 15.36 g
6. customRecrystallization from 1-chlorobutane
7. customgave material with m.p. 110°-111.5° C.