Thioglycerol → 5-(2,3-Dihydroxypropylthio)thiophene-2-sulfonamide

A solution of 2,3-dihydroxypropanethiol (8.11 g, 0.075 mol) in DMF (10 ml) was added dropwise to a stirred mixture of NaH (3.45 g, 50% oil, 0.075 mol) and DMF (40 ml) under nitrogen. When gas evolution was complete, a solution of N,N-dimethyl-N'-(5-bromothiophene-2-sulfonyl)formamidine (14.85 g, 0.05 mol) in DMF (50 ml) was added rapidly and the resulting mixture was heated on the steam bath for one hour. After an additional 16 hours at ambient temperature, the reaction mixture was diluted with water (500 ml) and extracted with ethyl acetate (250 ml). Sodium hydroxide (100 g) was added to the aqueous layer and this solution warmed on the steam bath for two hours. After cooling to ambient temperature, the mixture was filtered and the clear filtrate was acidified with concentrated HCl. The solution was extracted with ethyl acetate (3×300 ml), the extracts were washed with saturated NaCl and dried (Na2SO4) Filtration and evaporation of the solvent left the product as a light amber oil, 13.3 g.

1. temperaturethe resulting mixture was heated on the steam bath for one hour
2. extractionextracted with ethyl acetate (250 ml)
3. additionSodium hydroxide (100 g) was added to the aqueous layer
4. temperaturethis solution warmed on the steam bath for two hours
5. filtrationthe mixture was filtered
6. extractionThe solution was extracted with ethyl acetate (3×300 ml)
7. washthe extracts were washed with saturated NaCl
8. customdried
9. filtration(Na2SO4) Filtration and evaporation of the solvent
10. waitleft the product as a light amber oil, 13.3 g

ORD record

ord-355cc4ede3704656aaf6574ea32c2eb3

Source dataset

uspto-grants-1988_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04721794