反应详情

To a solution of 1-chloromethyl-3-methylsulfanyl-benzene (26.9 g, 0.156 mol) and 18-crown-6 (2 g, 7.8 mmol) in dry acetonitrile (100 mL) was added potassium cyanide and stirred at room temperature for 48 hours. A precipitate was formed while adding dichloromethane (400 mL). The suspension was filtered, washed with water (2×150 mL), dried (Na2SO4) concentrated and distilled under reduced pressure to give a colorless oil (22.9 g, 91%). MS: 161.9 (M+1−).

1. customA precipitate was formed
2. filtrationThe suspension was filtered
3. washwashed with water (2×150 mL)
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. distillationdistilled under reduced pressure