Hydrochloric Acid → 1-Hydroxy-2-(3-Methoxyphenyl)-6-Methoxynaphthalene

HRID 2414300Notes

Reaction equation

HRID 2414300 reaction equation
C([O:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=1)(=O)C.Cl>CO>[OH:4][C:5]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH3:16])=[CH:12][CH:13]=2)[CH:8]=[CH:7][C:6]=1[C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([O:23][CH3:24])[CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 129722071-Acetyloxy-2-(3-Methoxyphenyl)-6-Methoxynaphthalene

Product 1

HCID 129722081-Hydroxy-2-(3-Methoxyphenyl)-6-Methoxynaphthalene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension was prepared of 46.5 g of 1-acetyloxy-2-(3-methoxyphenyl)-6-methoxynaphthalene and 40 mL of 5N HCl in 400 mL of MeOH. The reaction mixture was heated to reflux for eleven hours. The reaction mixture was evaporated to a clear oil. This yielded 38.6 g of the title compound.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for eleven hours
  3. customThe reaction mixture was evaporated to a clear oil

Sources & evidence

ORD record
ord-051f06178e984adb8d497c6e9c52c663
Source dataset
uspto-grants-2004_11
Patent number
US06812244B2

Reaction notes

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