反应详情

A solution of 1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride (J.Med. Chem. 1998, 2157) (0.8 g), 2-(4-chloro-3-nitrobenzoyl)benzoic acid (0.9 g) and triethylamine (0.8 ml) in N,N-dimethylformamide (5 ml) was stirred at room temperature for 72 h. The mixture was partitioned between ethyl acetate and dilute hydrochloric acid, the organic layer was evaporated under reduced pressure. Purification was by chromatography eluting with 4% methanol/dichloromethane. The residue was triturated from methanol, yield 0.4 g as a solid.

1. customThe mixture was partitioned between ethyl acetate and dilute hydrochloric acid
2. customthe organic layer was evaporated under reduced pressure
3. customPurification
4. washeluting with 4% methanol/dichloromethane
5. customThe residue was triturated from methanol, yield 0.4 g as a solid