Triethylamine → HCID 10166111, compound

HRID 2414311Notes

Reaction equation

HRID 2414311 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=2[C:12]([O:14][CH3:15])=[O:13])=[O:9])=[CH:4][C:3]=1[N+:20]([O-:22])=[O:21].Cl.[Cl:24][C:25]1[CH:41]=[CH:40][C:28]2[CH2:29][O:30][C:31](=[O:39])[N:32]([CH:33]3[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]3)[C:27]=2[CH:26]=1.C(N(CC)CC)C>CN(C)C=O>[Cl:24][C:25]1[CH:41]=[CH:40][C:28]2[CH2:29][O:30][C:31](=[O:39])[N:32]([CH:33]3[CH2:34][CH2:35][N:36]([C:2]4[CH:7]=[CH:6][C:5]([C:8]([C:10]5[CH:19]=[CH:18][CH:17]=[CH:16][C:11]=5[C:12]([O:14][CH3:15])=[O:13])=[O:9])=[CH:4][C:3]=4[N+:20]([O-:22])=[O:21])[CH2:37][CH2:38]3)[C:27]=2[CH:26]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1499466020643-68-9HCID 22644655HCID 22644655, compound

Product 1

HCID 10166111HCID 10166111, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Methyl 2-[(4-chloro-3-nitrophenyl)carbonyl]benzoate (0.5 g), the product from step (ii) (0.47 g) and triethylamine (0.5 ml) in N,N-dimethylformamide (2.5 ml) were heated at 60° C. overnight. The mixture was evaporated under reduced pressure and the residue purified by chromatography eluting with 25% ethyl acetate/toluene. Yield 0.7 g of a solid.

Workup

  1. customThe mixture was evaporated under reduced pressure
  2. customthe residue purified by chromatography
  3. washeluting with 25% ethyl acetate/toluene

Sources & evidence

ORD record
ord-a4028a51d43f40efa5b3a88379a149a4
Source dataset
uspto-grants-2004_11
Patent number
US06812226B2

Reaction notes

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