Triethylamine → Ave-9488

HRID 2414356Notes

Reaction equation

HRID 2414356 reaction equation
Cl.[NH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1.C(N(CC)CC)C.[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>O1CCCC1>[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([NH:2][CH:3]2[CH2:11][C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4]2)=[O:25])=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 678794-Fluorobenzoyl chlorideHCID 1227642-Aminoindan hydrochloride

Product 1

HCID 10131276Ave-9488

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

43.70 g (258 mol) 2-aminoindane hydrochloride and 53.43 g (528 mmol) triethylamine were mixed with 250 ml of tetrahydrofuran, 42.89 g (270 mmol) 4-fluorobenzoylchloride were added, and the mixture was stirred for 2 h at RT.

Workup

  1. additionwere added

Sources & evidence

ORD record
ord-a2820dc76dda4b738b0a24a43e7cb416
Source dataset
uspto-grants-2004_11
Patent number
US06812253B2

Reaction notes

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