Hydrochloric Acid → Hydrochloric Acid

HRID 2414410Notes

Reaction equation

HRID 2414410 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][C:10]=1[O:17][CH2:18][CH2:19][NH:20]C(OC(C)(C)C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:28]>O1CCOCC1>[ClH:28].[NH2:20][CH2:19][CH2:18][O:17][C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:13]#[N:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 226451464-Benzyloxy-3-[2-(t-butoxycarbonylamino)ethoxy]benzonitrile

Product 2

HCID 313Hydrochloric AcidHCID 226451763-(2-Aminoethoxy)-4-benzyloxybenzonitrile

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3.4 g (9.2 mmol) of 4-benzyloxy-3-[2-(t-butoxycarbonylamino)ethoxy]benzonitrile was dissolved in 40 ml of 4 N solution of hydrogen chloride in dioxane, and the obtained solution was stirred overnight. The solvent was evaporated to obtain hydrochloride of the crude title compound.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-6ccd5f608d5d43d5b8e922188263b6b5
Source dataset
uspto-grants-2004_11
Patent number
US06812231B2

Reaction notes

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