Hydrochloric Acid → (2S,3S)-2-Amino-3-methyl-1-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-pentan-1-one Hydrochloride

HRID 2414457Notes

Reaction equation

HRID 2414457 reaction equation
C(OC(=O)[NH:7][C@H:8]([C:13]([N:15]1[CH2:19][C:18]([F:21])([F:20])[C:17]([F:23])([F:22])[CH2:16]1)=[O:14])[C@@H:9]([CH3:12])[CH2:10][CH3:11])(C)(C)C.[ClH:25]>C(OCC)(=O)C>[ClH:25].[NH2:7][C@@H:8]([C@@H:9]([CH3:12])[CH2:10][CH3:11])[C:13]([N:15]1[CH2:19][C:18]([F:20])([F:21])[C:17]([F:23])([F:22])[CH2:16]1)=[O:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86590627[(1S,2S)-2-Methyl-1-(3,3,4,4-tetrafluoro-pyrrolidine-1-carbonyl)-butyl]-carbamic acid tert-butyl ester

Product 1

HCID 9882539(2S,3S)-2-Amino-3-methyl-1-(3,3,4,4-tetrafluoro-pyrrolidin-1-yl)-pentan-1-one Hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

[(1S,2S)-2-Methyl-1-(3,3,4,4-tetrafluoro-pyrrolidine-1-carbonyl)-butyl]-carbamic acid tert-butyl ester (200 mg, 0.56 mmol) was dissolved in ethyl acetate (4 mL), cooled to about 0° C. and treated with gaseous hydrochloric acid for about 1 minute. After about 15 minutes at about 0° C. and about 30 minutes at room temperature, the mixture was concentrated to dryness and the solid was triturated with hexane, collected and dried under vacuum overnight (124 mg, 76%, melting point: greater than 250° C.).

Workup

  1. concentrationabout 30 minutes at room temperature, the mixture was concentrated to dryness
  2. customthe solid was triturated with hexane
  3. customcollected
  4. customdried under vacuum overnight (124 mg, 76%, melting point: greater than 250° C.)

Sources & evidence

ORD record
ord-71d03654bdd34c399f37660aaa74d91a
Source dataset
uspto-grants-2004_11
Patent number
US06812350B2

Reaction notes

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