反应详情

温度

0 °C

[(1S,2S)-2-Methyl-1-(3,3,4,4-tetrafluoro-pyrrolidine-1-carbonyl)-butyl]-carbamic acid tert-butyl ester (200 mg, 0.56 mmol) was dissolved in ethyl acetate (4 mL), cooled to about 0° C. and treated with gaseous hydrochloric acid for about 1 minute. After about 15 minutes at about 0° C. and about 30 minutes at room temperature, the mixture was concentrated to dryness and the solid was triturated with hexane, collected and dried under vacuum overnight (124 mg, 76%, melting point: greater than 250° C.).

1. concentrationabout 30 minutes at room temperature, the mixture was concentrated to dryness
2. customthe solid was triturated with hexane
3. customcollected
4. customdried under vacuum overnight (124 mg, 76%, melting point: greater than 250° C.)