3-Fluoropyridine → 2-(Pyridin-3-YL)octahydropyrrolo[3,4-C]pyrrole

HRID 2414716Notes

Reaction equation

F[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[CH:8]12[CH2:15][NH:14][CH2:13][CH:12]1[CH2:11][NH:10][CH2:9]2>>[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([N:10]2[CH2:11][CH:12]3[CH:8]([CH2:15][NH:14][CH2:13]3)[CH2:9]2)[CH:3]=1

Participants

Reactant 2

HCID 677943-Fluoropyridine

HCID 21867666Octahydropyrrolo(3,4-c)pyrrole

Product 1

HCID 99423512-(Pyridin-3-YL)octahydropyrrolo[3,4-C]pyrrole

Procedure

Prepared by heating 3-fluoropyridine and 3.7-Diazabicyclo[3.3.0]octane in an autoclave in the absence of solvent at 180° C. for 24 hours. Workup-procedure A/B.

Workup

customPrepared

Sources & evidence

ORD record: ord-7771e4dc6270468b841ae7a45871a638
Source dataset: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06815438B2

Reaction notes

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