反应详情

2.18 g of the compound obtained in Example 19a, 4.97g of carbon tetrabromide and 3.93 g of triphenylphosphine were added to 30 ml of tetrahydrofuran and the mixture was reacted overnight at room temperature. After the reaction was completed, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:1) to obtain 2.10 g of the title compound as pale yellow solid (yield: 75%).

1. customthe mixture was reacted overnight at room temperature
2. customthe solvent was evaporated under reduced pressure
3. customthe residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:1)