反应详情

A stirred suspension of 3,4,5-trimethoxyphenyl-2-oxoacetic acid (1.60 g, 6.66 mmoles) in dry methylene chloride (26 mL) at room temperature was treated with 2M oxalyl chloride in methylene chloride (14 mL, 4 equiv.) and dry dimethylformamide (1 drop). After 3 h the solvents were evaporated. The residue was flushed with dry methylene chloride (3×50 mL) and dried in vacuo for 2 h during which time a solid formed. The crude acid chloride was carried on without further purification.

1. customAfter 3 h the solvents were evaporated
2. customThe residue was flushed with dry methylene chloride (3×50 mL)
3. customdried in vacuo for 2 h during which time a solid
4. customformed
5. customThe crude acid chloride was carried on without further purification