HCID 22640158, compound → 1-biphenyl-4-yl-piperazine

HRID 2415143Notes

Reaction equation

HRID 2415143 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[Pd+2].[OH-]>[C:17]1([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:18]=[CH:19][C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:15][CH:16]=1

Participants

4

Reactant 1

HCID 22640158HCID 22640158, compound

Product 1

HCID 27355131-biphenyl-4-yl-piperazine

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

A suspension of 12.45 g (0.037 mol) of 1-benzyl-4-biphenyl-4-yl-piperazine and 4 g of palladium hydroxide in 360 ml of methanol is stirred for 6 hours at ambient temperature in a Parr apparatus under a hydrogen pressure of 50 psi. The catalyst is separated off and the filtrate is evaporated down.

Workup

  1. customThe catalyst is separated off
  2. customthe filtrate is evaporated down

Sources & evidence

ORD record
ord-59a29e27e8a44363bf5f47598bfd299e
Source dataset
uspto-grants-2004_11
Patent number
US06818644B1

Reaction notes

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