Heptane → HCID 22641070, compound

HRID 2415237Notes

Reaction equation

HRID 2415237 reaction equation
[CH3:1][C:2]1([CH3:28])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([Se:14][C:15]#[C:16][C:17]3[CH:27]=[CH:26][C:20]([C:21]([O:23]CC)=[O:22])=[CH:19][N:18]=3)[CH:5]=[CH:4][C:3]1=2.CCCCCCC>C1COCC1.[OH-].[Na+]>[CH3:1][C:2]1([CH3:28])[CH2:11][CH2:10][C:9]([CH3:12])([CH3:13])[C:8]2[CH:7]=[C:6]([Se:14][C:15]#[C:16][C:17]3[CH:27]=[CH:26][C:20]([C:21]([OH:23])=[O:22])=[CH:19][N:18]=3)[CH:5]=[CH:4][C:3]1=2

Participants

5

Reactant 2

HCID 8900HeptaneHCID 22641097HCID 22641097, compound

Product 1

HCID 22641070HCID 22641070, compoundYield 36%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 14798Sodium HydroxideSolvent

Procedure

In a manner similar to that of Example 7, by reaction of 600 mg (1.36 mmol) of ethyl 6-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanylethynyl)nicotinate in 30 ml of THF and 1 g of sodium hydroxide, and after trituration from heptane, 200 mg (36%) of the expected compound are obtained in the form of a yellow solid. m.p.=128° C.

Sources & evidence

ORD record
ord-706341bbf6814894956a7622e176ad13
Source dataset
uspto-grants-2004_11
Patent number
US06818666B2

Reaction notes

Loading…