4-Bromo-1-ethenyl-2-fluorobenzene → 4-Bromo-1-ethyl-2-fluorobenzene

HRID 2415252Notes

Reaction equation

HRID 2415252 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH2:9])=[C:4]([F:10])[CH:3]=1>C(OCC)(=O)C.[Pd]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH3:9])=[C:4]([F:10])[CH:3]=1

Participants

4

Reactant 1

HCID 166607744-Bromo-1-ethenyl-2-fluorobenzene

Product 1

HCID 226410574-Bromo-1-ethyl-2-fluorobenzene

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

4-Bromo-2-fluoro-1-vinyl-benzene (1.80 g, 8.96 mmol) was dissolved in ethyl acetate (50 mL) and palladium-on-carbon (10%, 70 mg) was added and the mixture was hydrogenated under 1 atmosphere overnight. The mixture was filtered and the filtrate was concentrated to give the crude, 1.80 g, which was used directly for the next step.

Workup

  1. customwas hydrogenated under 1 atmosphere overnight
  2. filtrationThe mixture was filtered
  3. concentrationthe filtrate was concentrated
  4. customto give the crude, 1.80 g, which

Sources & evidence

ORD record
ord-59db2a2efae84a179b953dc86a8ba6c1
Source dataset
uspto-grants-2004_11
Patent number
US06818663B2

Reaction notes

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