反应详情

A mixture of the 2-[6-(3-fluoro-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid ethyl ester (0.087 g, 0.234 mmol) (example 2) and lithium hydroxide (0.0062 g, 0.258 mmol) in water and tetrahydrofuran (1:1 v:v, 9 mL) was stirred at room temperature for 2 h. The THF was evaporated and the mixture acidified to pH 3-4 with 0.1N HCl. After extraction with ethyl acetate, drying of the organic layer with MgSO4, filtration and evaporation a white solid was obtained (0.080 g, 99%). MS: m/e=342.1 (M−H+).

1. customThe THF was evaporated
2. extractionAfter extraction with ethyl acetate
3. dry with materialdrying of the organic layer with MgSO4, filtration and evaporation a white solid
4. customwas obtained (0.080 g, 99%)