Aluminium lithium hydride → HCID 22641899, compound

HRID 2415450Notes

Reaction equation

HRID 2415450 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][O:7][C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[C:14](=O)[NH:13][CH2:12][CH2:11]3)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][C:8]2[CH:9]=[C:10]3[C:15](=[CH:16][CH:17]=2)[CH2:14][NH:13][CH2:12][CH2:11]3)=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22641896HCID 22641896, compound

Product 1

HCID 22641899HCID 22641899, compoundYield 98.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

As described for example 43, the title compound (1.86 g, 98%) was prepared from a mixture of 6-(4-fluoro-benzyloxy)-3,4-dihydro-2H-isoquinolin-1-one (2 g, 7.37 mmol) and lithium aluminum hydride (0.559 g, 14.74 mmol) in tetrahydrofuran. MS: m/e=258.0 (M+H+)

Sources & evidence

ORD record
ord-c1764dbad2244da4b227bf838c98eed9
Source dataset
uspto-grants-2004_11
Patent number
US06818774B2

Reaction notes

Loading…