Potassium Carbonate → HCID 22641889, compound

HRID 2415455Notes

Reaction equation

HRID 2415455 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Br)=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+]>O>[F:12][C:13]1[CH:20]=[CH:19][C:16]([CH2:17][O:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[C:7](=[O:11])[CH2:6][CH2:5]3)=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 680214-Fluorobenzyl bromideHCID 2331475-Hydroxy-1-indanone

Product 1

HCID 22641889HCID 22641889, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The 5-hydroxy-1-indanone (20 g, 134.9 mmol) was solved in dry in N,N′-dimethylformamide (120 mL) and the 4-fluorobenzyl bromide (18.2 mL, 148.4 mmol) was added followed by potassium carbonate anhydrous (24.2 g, 175.4 mmol) and the mixture was stirred for 12 h to 110 IC. Water was added and the resulting precipitate was filtrated and dried (34.6 g, 100%). MS: m/e=256.1 (M+).

Workup

  1. dry with materialin dry in N,N′-dimethylformamide (120 mL)
  2. filtrationthe resulting precipitate was filtrated
  3. customdried (34.6 g, 100%)

Sources & evidence

ORD record
ord-24b5c87ff37f415ebf5931d350cb990d
Source dataset
uspto-grants-2004_11
Patent number
US06818774B2

Reaction notes

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