Benzonitrile, 4-bromo- → 4-(2-Methyl-4-pyrrolidin-1-yl-quinolin-7-yloxy)-benzonitrile

HRID 2415489Notes

Reaction equation

HRID 2415489 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([OH:17])=[CH:7][CH:8]=2)[N:3]=1.Br[C:19]1[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=1>>[CH3:1][C:2]1[CH:11]=[C:10]([N:12]2[CH2:16][CH2:15][CH2:14][CH2:13]2)[C:9]2[C:4](=[CH:5][C:6]([O:17][C:19]3[CH:26]=[CH:25][C:22]([C:23]#[N:24])=[CH:21][CH:20]=3)=[CH:7][CH:8]=2)[N:3]=1

Participants

3

Reactant 2

HCID 12162Benzonitrile, 4-bromo-HCID 1358041182-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol

Product 1

HCID 226414454-(2-Methyl-4-pyrrolidin-1-yl-quinolin-7-yloxy)-benzonitrile

Procedure

In analogy to example 6 there was prepared: on reaction of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol with 4-bromobenzonitrile, whereby the product was isolated as free base, 4-(2-methyl-4-pyrrolidin-1-yl-quinolin-7-yloxy)-benzonitrile as a white solid. ISP mass spectrum, m/e 330.5 (M+1 calculated for C21H19N3O: 330).

Workup

  1. customIn analogy to example 6 there was prepared

Sources & evidence

ORD record
ord-7c5a82aefd504c80aa6fcd08c462bd81
Source dataset
uspto-grants-2004_11
Patent number
US06818767B2

Reaction notes

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