反应详情

A saturated solution of hydrogen chloride in ethyl acetate (6 mL) was added to a solution of tert-butyl 4-[4-chloro-2-(2-methoxy-2-oxoethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (1-5) (0.950 g, 2.60 mmol) in methylene chloride (6 mL) at 0° C. After 1 h, the volatiles were evaporated in vacuo, and the crude residue triturated twice with dry diethyl ether to give 1-6 (0.690 g) as a flocculent pale yellow solid (m/z (ES) 266 (MH+).

1. customthe volatiles were evaporated in vacuo
2. customthe crude residue triturated twice with dry diethyl ether