Hydrochloric Acid → HCID 86590371, compound

HRID 2415541Notes

Reaction equation

HRID 2415541 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=2)=[C:5]([CH2:22][C:23]([O:25][CH3:26])=[O:24])[CH:4]=1>C(OCC)(=O)C.C(Cl)Cl>[ClH:2].[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=2)=[C:5]([CH2:22][C:23]([O:25][CH3:26])=[O:24])[CH:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22640774Tert-Butyl 4-[4-Chloro-2-(2-Methoxy-2-Oxoethyl)Phenyl]-3,6-Dihydropyridine-1(2H)-Carboxylate

Product 1

HCID 86590371HCID 86590371, compoundYield 175.6%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

A saturated solution of hydrogen chloride in ethyl acetate (6 mL) was added to a solution of tert-butyl 4-[4-chloro-2-(2-methoxy-2-oxoethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (1-5) (0.950 g, 2.60 mmol) in methylene chloride (6 mL) at 0° C. After 1 h, the volatiles were evaporated in vacuo, and the crude residue triturated twice with dry diethyl ether to give 1-6 (0.690 g) as a flocculent pale yellow solid (m/z (ES) 266 (MH+).

Workup

  1. customthe volatiles were evaporated in vacuo
  2. customthe crude residue triturated twice with dry diethyl ether

Sources & evidence

ORD record
ord-655cf3a7d2ab42c3b290e51a5112707d
Source dataset
uspto-grants-2004_11
Patent number
US06818658B2

Reaction notes

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