Hydrochloric Acid → HCID 22640763, compound

HRID 2415547Notes

Reaction equation

HRID 2415547 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:10][CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH:14]=2)=[C:5]([CH:22]([CH3:27])[C:23]([O:25][CH3:26])=[O:24])[CH:4]=1>C(OCC)(=O)C.C(Cl)Cl>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH:10]=2)=[C:5]([CH:22]([CH3:27])[C:23]([O:25][CH3:26])=[O:24])[CH:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22640760tert-butyl 4-[4-chloro-2-(2-methoxy-1-methyl-2-oxoethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate

Product 1

HCID 22640763HCID 22640763, compoundYield 112.6%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

A saturated solution of hydrogen chloride in ethyl acetate (6 mL) was added to a solution of tert-butyl 4-[4-chloro-2-(2-methoxy-1-methyl-2-oxoethyl)phenyl]-3,6-dihydropyridine-1(2H)-carboxylate (0.730 g, 1.92 mmol) in methylene chloride (6 mL) at 0° C. After 1 h, the volatiles were evaporated in vacuo, and the crude residue triturated twice with dry diethyl ether to give 2-3 (0.605 g) (m/z (ES) 280 (MH+).

Workup

  1. customthe volatiles were evaporated in vacuo
  2. customthe crude residue triturated twice with dry diethyl ether

Sources & evidence

ORD record
ord-57ad8aee05f3407bae2dd52d5f6dc464
Source dataset
uspto-grants-2004_11
Patent number
US06818658B2

Reaction notes

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