Toluene → HCID 69923056, compound

HRID 2415634Notes

Reaction equation

HRID 2415634 reaction equation
[CH3:1][C@@H:2]([O:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25]C(=O)C)=[CH:21][CH:20]=2)=[CH:15][CH:14]=1)=[O:12])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].C1(C)C=CC=CC=1.CN>CO>[CH3:1][C@@H:2]([O:10][C:11]([C:13]1[CH:14]=[CH:15][C:16]([C:19]2[CH:20]=[CH:21][C:22]([OH:25])=[CH:23][CH:24]=2)=[CH:17][CH:18]=1)=[O:12])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

5

Reactant 3

HCID 1140TolueneHCID 6329MethylamineHCID 69922801HCID 69922801, compound

Product 1

HCID 69923056HCID 69923056, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A reactor was charged with 14 g (36 mmol) of (R)-1-methyloctyl-4′-acetoxybiphenyl-4-carboxylate and 150 ml of toluene, 5.7 g of a methanol solution containing 40% methylamine (73 mmol % of methylamine) was dropwise added, and a mixture was stirred at room temperature for 3 hours.

Workup

  1. additionwas dropwise added

Sources & evidence

ORD record
ord-12e8a36f808141da88e11960e130f365
Source dataset
uspto-grants-2004_11
Patent number
US06821581B2

Reaction notes

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