Triethylamine → HCID 136347703, compound

HRID 2415753Notes

Reaction equation

HRID 2415753 reaction equation
[C:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)#[N:2].Cl.[NH2:12][OH:13].C(N(CC)CC)C>CO>[OH:13][N:12]=[C:1]([C:3]1[C:4](=[O:10])[NH:5][C:6](=[O:9])[NH:7][CH:8]=1)[NH2:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 781455-CyanouracilHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 136347703HCID 136347703, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-Cyano uracil (2.0 g, 14.6 mmol) was suspended in methanol (50 mL), then hydroxylamine hydrochloride (1.4 g, 20.0 mmol) and triethylamine (2.8 mL, 20.0 mmol) were added and the mixture was heated to reflux overnight. The mixture was cooled to room temperature, the solid was collected by filtration, washed with methanol and dried to give the title compound as a pale yellow solid (1.8 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux overnight
  3. filtrationthe solid was collected by filtration
  4. washwashed with methanol
  5. customdried

Sources & evidence

ORD record
ord-847b5d1e0bfe4579a03ca873d9a9f2b9
Source dataset
uspto-grants-2004_11
Patent number
US06821972B2

Reaction notes

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