Triethylamine → 468068-81-7

HRID 2415765Notes

Reaction equation

HRID 2415765 reaction equation
[CH3:1][NH:2][C:3]1[C:8]([C:9]#[N:10])=[N:7][CH:6]=[CH:5][N:4]=1.C(N(CC)CC)C.Cl.[NH2:19][OH:20]>CO>[OH:20][N:19]=[C:9]([C:8]1[C:3]([NH:2][CH3:1])=[N:4][CH:5]=[CH:6][N:7]=1)[NH2:10]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 82114063352-06-7

Product 1

HCID 136347705468068-81-7

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methylamino-3-cyanopyrazine (J. Heterocycl. Chem. 1992, 29, 1689-92) (0.37 g, 2.8 mmol) in methanol (10 mL) was added triethylamine (0.4 mL, 2.8 mmol) followed by hydroxylamine hydrochloride (0.19 g, 2.8 mmol) and the reaction was stirred at room temperature for 4 hours. The mixture was filtered, the filtrate was then evaporated to dryness. The residue was dissolved in ethyl acetate (50 mL) and washed with water (50 mL). The organic layer was dried (MgSO4) and the solvent was removed in vacuo to give the title compound was a white solid (0.45 g).

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was then evaporated to dryness
  3. dissolutionThe residue was dissolved in ethyl acetate (50 mL)
  4. washwashed with water (50 mL)
  5. dry with materialThe organic layer was dried (MgSO4)
  6. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-d920da5ca2c3439ea36a9f1d6e43b2c7
Source dataset
uspto-grants-2004_11
Patent number
US06821972B2

Reaction notes

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