Sodium Hydroxide → HCID 22636735, compound

HRID 2415785Notes

Reaction equation

HRID 2415785 reaction equation
C[O:2][C:3]([C:5]1[C:15]2[O:14][CH2:13][CH2:12][CH2:11][O:10][C:9]=2[C:8]([NH:16][C:17]([C:19]2[NH:20][C:21]3[C:26]([CH:27]=2)=[CH:25][CH:24]=[CH:23][CH:22]=3)=[O:18])=[CH:7][CH:6]=1)=[O:4].[OH-].[Na+]>C1COCC1>[NH:20]1[C:21]2[C:26](=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH:27]=[C:19]1[C:17]([NH:16][C:8]1[C:9]2[O:10][CH2:11][CH2:12][CH2:13][O:14][C:15]=2[C:5]([C:3]([OH:4])=[O:2])=[CH:6][CH:7]=1)=[O:18]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 12132339HCID 12132339, compound

Product 1

HCID 22636735HCID 22636735, compoundYield 47.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

9-[(1H-indole-2-carbonyl)amino]-3,4-dihydro-2H-benzo[b][1,4]dioxepine-6-carboxylic acid methyl ester (E-2; R=H; 50 mg) was combined with 1 mL of THF and 1 mL of 1M NaOH and the reaction stirred for 4 days at room temperature. The solid was collected on a filter to yield 23 mg of a solid. LCMS: AP+ 353.

Workup

  1. customThe solid was collected on
  2. filtrationa filter

Sources & evidence

ORD record
ord-c0e73d1ff45f43cfaa13e2c9d4f74144
Source dataset
uspto-grants-2004_11
Patent number
US06821977B2

Reaction notes

Loading…