Piperazine → 2-(Piperazin-1-yl)-1,3-benzoxazole

HRID 2415847Notes

Reaction equation

HRID 2415847 reaction equation
Cl[C:2]1[O:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1.C(N(CC)CC)C>ClCCl>[N:11]1([C:2]2[O:3][C:4]3[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=3[N:6]=2)[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 4837PiperazineHCID 8471TriethylamineHCID 119862-Chlorobenzoxazole

Product 1

HCID 6478182-(Piperazin-1-yl)-1,3-benzoxazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 1.5 g (0.01 mol) of chlorobenzoxazole in 20 ml of dichloromethane is added dropwise at 0° C. to a solution of 1 g (0.012 mol) of piperazine and 7 ml (0.05 mol) of triethylamine in 10 ml of dichloromethane and the mixture is stirred for one hour at this temperature. Then it is extracted with water. The organic phase is dried over sodium sulphate, the drying agent is filtered off and the filtrate is concentrated by evaporation. The residue is washed with acetone.

Workup

  1. extractionThen it is extracted with water
  2. dry with materialThe organic phase is dried over sodium sulphate
  3. filtrationthe drying agent is filtered off
  4. concentrationthe filtrate is concentrated by evaporation
  5. washThe residue is washed with acetone

Sources & evidence

ORD record
ord-f2dcdf587287482183872732b039090e
Source dataset
uspto-grants-2004_11
Patent number
US06821967B2

Reaction notes

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