Sodium Iodide → HCID 22636917, compound

HRID 2416303Notes

Reaction equation

HRID 2416303 reaction equation
[CH3:1][Sn:2]([CH3:11])([CH3:10])[C:3]1[S:7][C:6]([CH2:8][OH:9])=[CH:5][CH:4]=1.[I-].[Na+].Cl[CH2:15][C:16]([N:18]1[CH2:23][CH2:22][S:21][CH2:20][CH2:19]1)=[O:17]>>[N:18]1([C:16](=[O:17])[CH2:15][O:9][CH2:8][C:6]2[S:7][C:3]([Sn:2]([CH3:11])([CH3:10])[CH3:1])=[CH:4][CH:5]=2)[CH2:23][CH2:22][S:21][CH2:20][CH2:19]1

Participants

4

Reactant 3

HCID 5238Sodium IodideHCID 18918637HCID 18918637, compoundHCID 22636973HCID 22636973, compound

Product 1

HCID 22636917HCID 22636917, compound

Procedure

The 1-thiomorpholin-4-yl-2-(5-trimethylstannanyl-thiophen-2-ylmethoxy)-ethanone employed is prepared analogously to example (3a) (stage b)) starting from (5-trimethylstannanyl-thiophen-2-yl)-methanol (7.66 g; 27.67 mmol; described, in example (3a), stage a)), sodium iodide (4.07 g; 27.34 mmol) and 2-chloro-1-thiomorpholiri-4-yl-ethanone (5.92 g; 32.94 mmol)

Sources & evidence

ORD record
ord-681e745c06394b75adb880faeba41a1c
Source dataset
uspto-grants-2004_11
Patent number
US06821980B1

Reaction notes

Loading…