反应详情

Analogously to example (4a), starting from 4-(4-bromo-2-fluoro-benzyl)-morpholine (274 mg; 1 mmol), bis(pinacolato)diboron (380 mg; 1.5 mmol), potassium acetate (294 mg; 3 mmol), bis(triphenylphosphine)palladium(II) dichloride (47 mg; 0.07 mmol) and from 5-(3,5-diethoxy-4-iodo-benzyl)-pyrimidine-2,4-diamine (example 1) (248 mg; 0.6 mmol), 166 mg (34%) 5-(2,6-diethoxy-3′-fluoro-4′-morpholin-4-ylmethyl-biphenyl-4-ylmethyl)-pyrimidine-2,4-diamine are obtained as a pale yellow powder.

1. customare obtained as a pale yellow powder