反应详情

温度

50 °C

Mixture of tert-butyl 3-(acetylthio)azetidine-1-carboxylate (STEP C, 700 mg, 3.03 mmol), methanol (10 mL) and potassium carbonate (836 mg, 6.05 mol) was stirred at 50° C. for 2 h and cooled to room temperature. To the reaction mixture was added 2 mol/L hydrochloric acid for solution acidified (pH <4). The resulting solution was extracted with diethyl ether (30 mL×2). The organic layer was combined and washed with water (30 mL×2) and brine (30 mL). The extract was dried with magnesium sulfate and concentrated. Resulting crude product (581 mg) was used without further purification.

1. temperaturecooled to room temperature
2. extractionThe resulting solution was extracted with diethyl ether (30 mL×2)
3. washwashed with water (30 mL×2) and brine (30 mL)
4. dry with materialThe extract was dried with magnesium sulfate
5. concentrationconcentrated