反应详情

温度

70 °C

4.0 g (12.7 mmol) of 1-amino-7-hydroxyisoquinoline monohydrobromide was dissolved in 50 ml of DMF. 4.42 g (18.6 mmol) of t-butyl (3-chloropropyl)carbamate, 8.76 g (63.5 mmol) of potassium carbonate and 4.69 g (12.7 mmol) of tetrabutylammonium iodide were added to the obtained solution, and they were stirred at 70° C. for 3 days. After the treatment with dichloromethane as the extraction solvent in an ordinary manner, the crude product was obtained, which was then purified by the silica gel column chromatography to obtain the title compound.

1. customwhich was then purified by the silica gel column chromatography